PKQuest_Java: free, interactive physiologically based pharmacokinetic software package and tutorial
نویسندگان
چکیده
منابع مشابه
Interspecies extrapolation by physiologically based pharmacokinetic modeling
Recently, Christoph Thiel and colleagues from Aachen University published an improved physiologically based pharmacoki-netik modeling (PBPK) technique for mouse to human extrapolation (Thiel et al., 2015). This publication will be awarded by the Ebert Prize 2016 of the American Pharmacist Association, which represents the oldest pharmacy award in the United States. The translation of preclinica...
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Rapid expansion of nanoparticle research demands new technologies that will enable better interpretation of experimental data and assistance in the rational design of future nanoparticles. The use of physiologically based pharmacokinetic (PBPK) models may serve as powerful tools to meet these needs. PBPK models have been successfully applied for the study of the absorption, distribution, metabo...
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Exposure to multiple chemicals may cause significant alterations of tissue dose of the toxic moiety of one or more of the individual chemicals. The change in target tissue dose of a chemical present in simple mixtures can be predicted when the determinants of disposition of each chemical, and the mechanism of toxicokinetic interaction between chemicals are understood at a quantitative level. De...
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Physiologically based pharmacokinetic models are being used in an increasing number of different areas. However, they are perceived as complex, data hungry, resource intensive, and time consuming. In addition, model validation and verification are hindered by the relative complexity of the equations. To begin to address these issues a web application called MEGen for the rapid construction and ...
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ژورنال
عنوان ژورنال: BMC Research Notes
سال: 2009
ISSN: 1756-0500
DOI: 10.1186/1756-0500-2-158